IDDF2024-ABS-0321 Development and initial use of a new IBD clinical database with the Eastern and Western characteristics

<h3>Background</h3> The increasing global prevalence of inflammatory bowel disease (IBD) has become a major medical and social issue. The IBD database is the basis of disease research and management. The development of an IBD database with Eastern and Western characteristics is of great potential for collaborative research on IBD. <h3>Methods</h3> We developed a new IBD database which named the 301 IBD database, that integrated the IBD clinical characteristics of China and America. The 301 IBD database is based on the Penn IBD database and the latest IBD guidelines and consensus of China. A single-center analysis of the clinical data of UC and CD from the Chinese PLA General Hospital from 2008 to 2023 was conducted. <h3>Results</h3> The 301 IBD database contains 490 items in 6 sections, including demographic characteristics, personal history, clinical phenotype, disease activity, examination, and treatment, compared with the Penn IBD database, which has 241 items. Features of the 301 IBD database include inpatient focus, biochemical indicators and opportunistic infection test focus, and more about UC-associated complications. We then applied the 301 IBD database to record and analyze the clinical data of UC and CD inpatients from the Chinese PLA General Hospital from 2008 to 2023. A total of 1053 UC cases (1944 hospitalizations) and 305 CD cases (661 hospitalizations) had been recorded. Hospitalization of IBD patients showed an increasing trend, from 2.35% in 2008 to 3.95% in 2023. The new IBD database showed that partial clinical characteristics of Chinese UC inpatients are predominantly male (62.5%), extensive lesions (55.1%), low usage of biologics (4.1%), and a high incidence of UC-CRC (3.0%). The clinical features of CD include male predominant (68.5%), mainly ileal involvement (39.0%), presenting with non-stricturing, non-penetrating phenotype (66.2%), high rate of extraintestinal manifestation (24.3%) and surgical intervention (24.9%). <h3>Conclusions</h3> A new IBD clinical database has been formed with Eastern and Western characteristics. It will provide a common database basis for Eastern and Western collaborative research on IBD in the future.