Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
In this cross-sectional study of individuals with recent-onset psychosis compared with healthy controls, a lower hippocampal α7-nAChR availability was found in recent-onset psychosis, and its availability was lower in those with nonaffective vs affective psychosis. Further study of the association between low availability of the α7-nAChR and recent-onset psychosis is warranted toward informing diagnostic or therapeutic strategies related to these findings.
Authors
- Ana R. Soule
- Mark Yoon
- Robert F. Dannals (ORCID: https://orcid.org/0000-0002-5483-5914)
- Katelyn Jenkins
- Leah H. Rubin (ORCID: https://orcid.org/0000-0003-2749-6328)
- Martin G. Pomper (ORCID: https://orcid.org/0000-0001-6753-3010)
- Steven P. Rowe (ORCID: https://orcid.org/0000-0003-2897-4694)
- Wojciech G. Lesniak (ORCID: https://orcid.org/0000-0003-0734-4685)
- Courtney K. Harrington (ORCID: https://orcid.org/0009-0001-8932-6415)
- Laura K. Shinehouse
- Jennifer M. Coughlin (ORCID: https://orcid.org/0000-0002-2514-9640)
- Vidyulata Kamath (ORCID: https://orcid.org/0000-0001-7711-3597)
- Yong Du (ORCID: https://orcid.org/0000-0002-0237-6154)
- Jessica J. Kilgore
- Andrew G. Horti (ORCID: https://orcid.org/0000-0003-2290-488X)
- Nicole R. Wong
Institutions
- University of North Carolina at Chapel Hill (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.27163
- Citations
- 8
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Johns Hopkins University
- One Mind
- National Institutes of Health
- National Center for Advancing Translational Sciences