IDDF2024-ABS-0450 Evolving burden of pancreatic cancer and its trend in 204 countries and territories from 1990-2021: a benchmarking comparative and consistent analysis

<h3>Background</h3> Pancreatic cancer (PC) poses a profound health challenge globally, standing as the sixth most deadly cancer type. This pioneering study evaluates the global impact of PC over the past three decades, including the initial two years of the COVID-19 pandemic, a period that notably strained the management of non-COVID illnesses, especially cancers. <h3>Methods</h3> Utilizing the Global Burden of Disease framework, we assessed the prevalence, incidence, deaths, disability-adjusted life years (DALYs), and years lived with disability (YLDs) due to PC by age, sex, year, and location across 204 countries and territories. Non-fatal health outcomes were estimated using the DISMOD-MR 2.1 meta-regression tool, while fatal outcomes were analyzed using the cause of death ensemble model (CODEm). <h3>Results</h3> From 1990-2021, the total prevalence of PC rose from 172,808 (with a 95% uncertainty interval of 164,345-180,916) to 439,000 (401,738-471,000) (IDDF2024-ABS-0450 Figure 1. Age-standardized rate global trend, IDDF2024-ABS-0450 Figure 2. All age counts global trend). The total percentage change in the age-standardized incidence rate (ASIR) increased by 9% (ranging from 1% to 17%), the mortality rate (ASMR) by 5% (3%-13%), and the DALYs rate (ASDALR) by 1% (from -8% to 10%) (IDDF2024-ABS-0450 Figure 3. Incidence rate ASIR global, IDDF2024-ABS-0450 Figure 4. Mortality rate ASMR global, IDDF2024-ABS-0450 Figure 5. Dalys rate ASDALR global). Regionally, the highest increases in ASMR were observed in Western Sub-Saharan Africa at 92% (61%-135%). Low-middle income countries under the Socio-demographic Index (SDI) witnessed the greatest increases in ASMR, at 57% (35%-89%). Among age groups, individuals under 70 years saw the most significant rises in ASMR, by 39% (25%-53%) and ASIR, by 42% (28%-56%) from 1990-2021 (IDDF2024-ABS-0450 Figure 6. Combined image age-wise distribution). Overall, males experienced a higher burden compared to females, with increases in ASIR (11% vs 7%), ASMR (7% vs 3%), and YLDs rate (11% vs 7%). <h3>Conclusions</h3> In 2021, PC accounted for 5.11% of all cancer-related deaths. The pandemic highlighted a critical need for preparedness to manage the burden of such diseases effectively in future global health crises. From the perspectives of public health stakeholders, policymakers, and clinicians, this calls for a robust strategy to combat and mitigate the impact of pancreatic cancer, ensuring better management and outcomes even during challenging times.