Upregulation of MELK promotes chemoresistance and induces macrophage M2 polarization via CSF-1/JAK2/STAT3 pathway in gastric cancer
Our investigation underscores the critical role of MELK in promoting chemoresistance and inducing M2 macrophage polarization in GC. It proposes novel targets and methods for the treatment of GC, as well as prognostic factors for neoadjuvant chemotherapy.
Authors
- Pengfei Su (ORCID: https://orcid.org/0000-0002-5109-0793)
- Hongyun Huang (ORCID: https://orcid.org/0000-0002-6507-5703)
- Weiming Kang (ORCID: https://orcid.org/0000-0002-6736-4728)
- Moxi Chen
- Yu Tian (ORCID: https://orcid.org/0000-0001-6645-269X)
- Can Cao (ORCID: https://orcid.org/0000-0001-7011-9435)
- Yingjing Zhang (ORCID: https://orcid.org/0000-0002-5584-7925)
- Jianchun Yu (ORCID: https://orcid.org/0000-0002-8250-7475)
- Yuqin Liu (ORCID: https://orcid.org/0009-0009-2315-5914)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12935-024-03453-8
- Citations
- 10
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.40