IDDF2024-ABS-0098 Efficacy and patient tolerability of magnesium sulfate, sodium sulfate and potassium sulfate concentrate oral solution compared to the polyethylene glycol solution for bowel preparation in colonoscopy

<h3>Background</h3> The efficacy of colonoscopy is dependent on the quality of the pre-colonoscopy bowel preparation. We conducted a prospective study to investigate the efficacy and patient tolerability of Magnesium Sulfate, Sodium Sulfate and Potassium Sulfate (MSSSPS) concentrate oral solution compared to Polyethylene Glycol (PEG) solution for colonoscopy bowel preparation. <h3>Methods</h3> Eighty patients who underwent colonoscopy in our center from March 1st, 2024, to March 31st, 2024, were enrolled in our study. They were randomly divided into two groups (40 patients in MSSSPS group while 40 in PEG group). The primary outcome was colon cleanliness, assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes included tolerability of the bowel preparation, endoscopic diagnosis, and serious adverse events. <h3>Results</h3> The overall quality of colon cleansing was similar in both groups (mean BBPS were 7.93±1.12 in MSSSPS group and 6.00±1.38 in PEG group, P=0.19). Mean inward and outward procedure times were not statistically different in MSSSPS group and PEG group (2.32±0.52min vs 2.42±0.50min, P=0.66 and 6.6±1.01min vs 7.32±1.10min, P=0.21 respectively). Patients found preparation with MSSSPS to be easier than PEG, with less bowel movement frequency (P=0.49) and better taste (p=0.17), though there was no statistically significant difference. No clinically important adverse effects were seen with either method of preparation (P=0.24). MSSSPS was associated with increased patient tolerability and compliance. <h3>Conclusions</h3> Preparation with MSSSPS concentrate oral solution is a well-tolerated and efficacious alternative to conventional PEG solution for bowel preparation in colonoscopy.