Access to Piperazine-Fused Pyrrolocarbazoles Enabled by Acid-Catalyzed Stereoselective Hydroarylation of Ynamide–Indoles and Subsequent Diels–Alder Reactions/Aromatizations
Pyrrolocarbazole skeletons are well known to possess a variety of biological activities that might be therapeutically useful in the treatment of cancers. Herein, an acid-catalyzed stereoselective hydroarylation/Diels-Alder cycloaddition/aromatization of ynamide-indoles is described. We newly designed and synthesized a variety of piperazine-fused pyrrolocarbazole derivatives that could be further applied to the synthesis of potent Wee1 inhibitors.
Authors
- Ze Zhou
- Jin‐Ming Yang (ORCID: https://orcid.org/0000-0001-6829-092X)
- Bin Wu (ORCID: https://orcid.org/0000-0003-4315-6286)
- Qingyi Wei
- Xiang Huang (ORCID: https://orcid.org/0009-0004-1145-1197)
- Yilin Wang (ORCID: https://orcid.org/0009-0003-7583-4704)
Institutions
- Minzu University of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1021/acs.orglett.4c01889
- Citations
- 3
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- South-Central University for Nationalities
- Fundamental Research Funds for the Central Universities