Efficacy of pegylated Graphene oxide quantum dots as a nanoconjugate sustained release metformin delivery system in in vitro insulin resistance model
Metformin, the primary therapy for type 2 diabetes mellitus (T2DM), showed limitations such as varying absorption, rapid system clearance, required large amount, resistance, longstanding side effects. Use of Nano formulations for pharmaceuticals is emerging as a viable technique to reduce negative consequences of drug, while simultaneously attaining precise release and targeted distribution. This study developed a Polyethylene Glycol conjugated Graphene Oxide Quantum dots (GOQD-PEG) nanocomposite for the sustained release of metformin. Herein, we evaluated the effectiveness of metformin-loaded nanoconjugate in in vitro insulin resistance model. Results demonstrated drug loaded nanoconjugate successfully restored glucose uptake and reversed insulin resistance in in vitro conditions at reduced dosage compared to free metformin.
Authors
- Kunal Sarkar (ORCID: https://orcid.org/0000-0001-9837-5350)
- Gausal A. Khan (ORCID: https://orcid.org/0000-0002-0306-6641)
- Alaa A. Al-Masud (ORCID: https://orcid.org/0000-0003-0758-9818)
- Madhusudan Das (ORCID: https://orcid.org/0000-0003-3748-892X)
- Srilagna Chatterjee
- S. S. De (ORCID: https://orcid.org/0000-0001-9120-8541)
- Arindam Chatterjee (ORCID: https://orcid.org/0000-0001-8977-1669)
- Kingshuk Dutta
- Biswabandhu Bankura
- Sarbashri Bank (ORCID: https://orcid.org/0000-0001-9603-1415)
- Nirvika Paul (ORCID: https://orcid.org/0000-0002-0269-6035)
- Dipankar Chattopadhyay (ORCID: https://orcid.org/0000-0002-0863-5882)
- Santanu Chakraborty (ORCID: https://orcid.org/0000-0002-7362-9091)
- Anwesha Das (ORCID: https://orcid.org/0000-0003-4110-0297)
Institutions
- University of Calcutta (IN)
- Princess Nourah bint Abdulrahman University (SA)
- Techno India University (IN)
- KPC Medical College and Hospital (IN)
- King Faisal University (SA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1371/journal.pone.0307166
- Citations
- 8
- Primary Topic
- Graphene and Nanomaterials Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Princess Nourah Bint Abdulrahman University