Treatments and clinical outcomes in stage II colon cancer patients with 12-gene Oncotype DX Colon Recurrence Score® assay-guided therapy: real-world data
RS results are prognostic in stage II CC. Among RS 41-100 patients, outcomes were better in CT-treated versus observation-only patients despite worse clinicopathologic characteristics, suggesting that CT confers clinical benefit in high-risk patients.
Authors
- Silvana Fennig (ORCID: https://orcid.org/0000-0002-7797-7296)
- I. Ben-Aharon
- C. T. Russell (ORCID: https://orcid.org/0000-0003-1639-8298)
- Lior Soussan‐Gutman
- B. Brenner
- Hillary Voet (ORCID: https://orcid.org/0000-0002-4928-365X)
- Nicky Liebermann
- Ravit Geva (ORCID: https://orcid.org/0000-0002-5380-4948)
- Avital Bareket‐Samish (ORCID: https://orcid.org/0000-0002-4849-7891)
- Gil Bar‐Sela (ORCID: https://orcid.org/0000-0001-6579-1841)
- Ayelet Shai (ORCID: https://orcid.org/0000-0001-9502-8441)
- Frederick L. Baehner (ORCID: https://orcid.org/0000-0001-6883-1212)
- Moshe Mishaeli
- Nirit Yarom
- Sofia Man
- R. Brenner
- Ayala Hubert
- K. Shulman
Institutions
- Tel Aviv University (IL)
- Technion – Israel Institute of Technology (IL)
- Hebrew University of Jerusalem (IL)
- Emek Medical Center (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Western Galilee Hospital (IL)
- Kaplan Medical Center (IL)
- Rabin Medical Center (IL)
- Soroka Medical Center (IL)
- Wolfson Medical Center (IL)
- Rambam Health Care Campus (IL)
- Meir Medical Center (IL)
- University Medical Center (US)
- Exact Sciences (United States) (US)
- University Hospital and Clinics (US)
- Rappaport Family Institute for Research in the Medical Sciences (IL)
- HealthInsight (US)
- Haifa Medical Center (IL)
- Clalit Health Services (IL)
Publication Details
- Journal
- ESMO Open
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.esmoop.2024.103648
- Citations
- 5
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- Gilead Sciences
- Genomic Health
- Astellas Pharma
- Faculty of Exact Sciences, Bar-llan University