Secoisolariciresinol diglucoside attenuates neuroinflammation and cognitive impairment in female Alzheimer’s disease mice via modulating gut microbiota metabolism and GPER/CREB/BDNF pathway
These findings suggest that SDG promotes the production of gut microbial metabolites END and ENL, which inhibit cerebral β-amyloid deposition, activate GPER to enhance CREB/BDNF signaling pathways, and suppress neuroinflammatory responses. Consequently, SDG exerts neuroprotective effects and ameliorates cognitive impairments associated with AD in female mice.
Authors
- Mengzhen Jia (ORCID: https://orcid.org/0000-0002-2458-3023)
- Zhigang Liu (ORCID: https://orcid.org/0000-0002-1363-6708)
- Jun Hu (ORCID: https://orcid.org/0000-0002-7282-2316)
- Jiao Chen (ORCID: https://orcid.org/0000-0003-2367-4369)
- Xuhui Chen (ORCID: https://orcid.org/0000-0002-9791-2051)
- Junqing Wen
- Fangjie Ning
- Xiaorui Wang (ORCID: https://orcid.org/0009-0003-6675-5094)
Institutions
- Peking University Shenzhen Hospital (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12974-024-03195-4
- Citations
- 25
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.93