Tetrahydrocurcumin ameliorates hepatic steatosis by restoring hepatocytes lipophagy through mTORC1-TFEB pathway in nonalcoholic steatohepatitis
THC restored lipophagy to reduce lipid accumulation by regulating mTORC1-TFEB pathway in NASH rats and steatosis hepatocytes. These findings suggested that THC represents a therapeutic candidate for NASH treatment.
Authors
- Haipiao Huang
- Hanbin Chen
- Fengkun Guan
- Shangbin Zhang
- Yuhong Liu (ORCID: https://orcid.org/0000-0001-9364-0039)
- Jianping Chen (ORCID: https://orcid.org/0000-0003-1892-9355)
- Jiazhen Wu
- Muxia Li (ORCID: https://orcid.org/0000-0003-3609-5251)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
- Southern University of Science and Technology (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1016/j.biopha.2024.117297
- Citations
- 13
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Sanming Project of Medicine in Shenzhen
- Basic and Applied Basic Research Foundation of Guangdong Province