Different Complement Activation Patterns Following C5 Cleavage in MOGAD and AQP4-IgG+NMOSD
The complement pathway is activated in both MOGAD and AQP4+NMOSD, but MAC formation is lower in MOGAD, particularly in those with mild attacks, than in AQP4+NMOSD. These findings may have pathogenetic and therapeutic implications in MOGAD.
Authors
- Tatsuro Misu (ORCID: https://orcid.org/0000-0002-7311-2578)
- Naoki Yamamoto
- Hirohiko Ono
- Hans Lassmann (ORCID: https://orcid.org/0000-0001-8617-5052)
- Ichiro Nakashima (ORCID: https://orcid.org/0000-0002-2612-8948)
- Yuki Matsumoto (ORCID: https://orcid.org/0000-0003-0163-8105)
- Kimihiko Kaneko (ORCID: https://orcid.org/0000-0001-8469-9338)
- T. Takahashi (ORCID: https://orcid.org/0000-0001-5237-3122)
- Naohiro Sakamoto
- Hiroshi Kuroda (ORCID: https://orcid.org/0000-0003-0421-3110)
- Masashi Aoki (ORCID: https://orcid.org/0000-0001-7284-1069)
- Shu Umezawa (ORCID: https://orcid.org/0000-0002-3067-9419)
- Juichi Fujimori (ORCID: https://orcid.org/0000-0001-7170-7853)
- Chihiro Namatame
- Kazuo Fujihara
- Naoya Yamazaki (ORCID: https://orcid.org/0000-0002-9158-5686)
- Yasuo Harigaya
- Yoshiki Takai
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1212/nxi.0000000000200293
- Citations
- 17
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 4.09
Funders
- Bristol-Myers Squibb
- Sanofi
- Biogen
- Alexion Pharmaceuticals
- CSL Behring
- Tohoku Medical and Pharmaceutical University
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Chugai Pharmaceutical
- Japan Society for the Promotion of Science