A Research Agenda to Improve Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disease: An Official American Thoracic Society Research Statement

<b>Background:</b> Individuals with chronic obstructive pulmonary disease (COPD) are often at risk for or have comorbid cardiovascular disease and are likely to die of cardiovascular-related causes. <b>Objectives:</b> To prioritize a list of research topics related to the diagnosis and management of patients with COPD and comorbid cardiovascular diseases (heart failure, atherosclerotic vascular disease, and atrial fibrillation) by summarizing existing evidence and using consensus-based methods. <b>Methods:</b> A literature search was performed. References were reviewed by committee co-chairs. An international, multidisciplinary committee, including a patient advocate, met virtually to review evidence and identify research topics. A modified Delphi approach was used to prioritize topics in real time on the basis of their potential for advancing the field. <b>Results:</b> Gaps spanned the translational science spectrum from basic science to implementation: <i>1</i>) disease mechanisms; <i>2</i>) epidemiology; <i>3</i>) subphenotyping; <i>4</i>) diagnosis and management; <i>5</i>) clinical trials; <i>6</i>) care delivery; <i>7</i>) medication access, adherence, and side effects; <i>8</i>) risk factor mitigation; <i>9</i>) cardiac and pulmonary rehabilitation; and <i>10</i>) health equity. Seventeen experts participated, and quorum was achieved for all votes (>80%). Of 17 topics, ≥70% agreement was achieved for 12 topics after two rounds of voting. The range of summative Likert scores was -15 to 25. The highest priority was "Conduct pragmatic clinical trials with patient-centered outcomes that collect both pulmonary and cardiac data elements." Health equity was identified as an important topic that should be embedded within all research. <b>Conclusions:</b> We propose a prioritized research agenda with the purpose of stimulating high-impact research that will hopefully improve outcomes among people with COPD and cardiovascular disease.

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Publication Details

Journal
American Journal of Respiratory and Critical Care Medicine
Published
2024-08-12
DOI
https://doi.org/10.1164/rccm.202407-1320st
Citations
14
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
Field-Weighted Citation Impact
5.87

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article

A Research Agenda to Improve Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disease: An Official American Thoracic Society Research Statement

Allan J. Walkey, Laura C. Myers, S. Shah, Peter K. Lindenauer et al.
14 citations
American Journal of Respiratory and Critical Care Medicine
Chronic Obstructive Pulmonary Disease (COPD) Research
5.87
article

A Research Agenda to Improve Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disease: An Official American Thoracic Society Research Statement

Allan J. Walkey, Laura C. Myers, S. Shah, Peter K. Lindenauer, Miguel Divo, Jennifer Kathleen Quint, Nathaniel M. Hawkins, Mark T. Dransfield, Surya Prakash Bhatt, Todd A. Lee, Valerie G. Press, Nirupama Putcha, R. Graham Barr, David M. Mannino, Leah J. Witt, Sadiya S. Khan, Andrea S. Gershon, Richard A. Mularski, Huong Q. Nguyen, J. Michael Wells, Alan Hamilton, Caroline Gainer
article en
14 citations

Abstract

<b>Background:</b> Individuals with chronic obstructive pulmonary disease (COPD) are often at risk for or have comorbid cardiovascular disease and are likely to die of cardiovascular-related causes. <b>Objectives:</b> To prioritize a list of research topics related to the diagnosis and management of patients with COPD and comorbid cardiovascular diseases (heart failure, atherosclerotic vascular disease, and atrial fibrillation) by summarizing existing evidence and using consensus-based methods. <b>Methods:</b> A literature search was performed. References were reviewed by committee co-chairs. An international, multidisciplinary committee, including a patient advocate, met virtually to review evidence and identify research topics. A modified Delphi approach was used to prioritize topics in real time on the basis of their potential for advancing the field. <b>Results:</b> Gaps spanned the translational science spectrum from basic science to implementation: <i>1</i>) disease mechanisms; <i>2</i>) epidemiology; <i>3</i>) subphenotyping; <i>4</i>) diagnosis and management; <i>5</i>) clinical trials; <i>6</i>) care delivery; <i>7</i>) medication access, adherence, and side effects; <i>8</i>) risk factor mitigation; <i>9</i>) cardiac and pulmonary rehabilitation; and <i>10</i>) health equity. Seventeen experts participated, and quorum was achieved for all votes (>80%). Of 17 topics, ≥70% agreement was achieved for 12 topics after two rounds of voting. The range of summative Likert scores was -15 to 25. The highest priority was "Conduct pragmatic clinical trials with patient-centered outcomes that collect both pulmonary and cardiac data elements." Health equity was identified as an important topic that should be embedded within all research. <b>Conclusions:</b> We propose a prioritized research agenda with the purpose of stimulating high-impact research that will hopefully improve outcomes among people with COPD and cardiovascular disease.

American Journal of Respiratory and Critical Care MedicineVol. 210(6)
Northwestern University (US), Brigham and Women's Hospital (US), Baystate Medical Center (US), Kaiser Permanente (US), University of British Columbia (CA), University of Kentucky (US), Johns Hopkins University (US), University of Massachusetts Chan Medical School (US), University of California, San Francisco (US), University of Washington (US), Johns Hopkins Medicine (US), University of Alabama at Birmingham (US), University of Illinois Chicago (US), University of Chicago (US), Massachusetts General Hospital (US), Neurobehavioral Systems (US), Kaiser Permanente Center for Health Research (US), Birmingham VA Medical Center (US), COPD Foundation (US), Institute for Clinical Evaluative Sciences (CA), Sunnybrook Hospital (CA), Sunnybrook Research Institute, Imperial College London (GB), Columbia University (US)
U.S. Department of Defense, Amgen, Pfizer, AstraZeneca, GlaxoSmithKline, Sanofi, Patient-Centered Outcomes Research Institute, Teva Pharmaceutical Industries, COPD Foundation, European Respiratory Society, Regeneron Pharmaceuticals, Canadian Thoracic Society, Society of Hospital Medicine, Insmed, Ontario Ministry of Economic Development and Innovation, National Institute for Health and Care Research, Ministero dello Sviluppo Economico, Grifols, Bavarian Nordic, Mereo BioPharma, National Institutes of Health, Health Resources and Services Administration, Genentech, University of California, San Francisco, Medical Research Council, National Heart, Lung, and Blood Institute, National Institute of Environmental Health Sciences, Department of Medicine, University of California, San Francisco
Good health and well-being
Openalex Percentile: Top 3%
Chronic Obstructive Pulmonary Disease (COPD) Research
5.87
DOIOpen Access PDFOpenAlex
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