Synthesis of Aryl Naphthoquinones and Maleimides <i>via</i> Pd(II)‐Catalyzed Template‐Assisted <i>m</i>−C(sp<sup>2</sup>)−H Functionalization Reaction
An efficient approach for the synthesis of substituted aryl naphthoquinones via a Pd(II)-catalyzed template-assisted m-C(sp<sup>2</sup>)-H bond functionalization reaction of arylmethane sulfonates have been demonstrated. The method involves usage of less expensive and abundant pharmacologically important scaffold naphthoquinone. A wide range of arylmethane sulfonates were examined and found to be compatible with the protocol. The protocol has also been further extended to the synthesis of various substituted aryl maleimide scaffolds. A plausible reaction mechanism has also been proposed to account for the selective distal m-C(sp<sup>2</sup>)-H bond functionalization reaction.
Authors
- Ananya Dutta (ORCID: https://orcid.org/0000-0002-8287-8970)
- Masilamani Jeganmohan (ORCID: https://orcid.org/0000-0002-7835-3928)
Institutions
- Indian Institute of Technology Madras (IN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1002/chem.202402162
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Institute of Technology Madras
- Science and Engineering Research Board