Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice
This suggests NGF-TrkA signaling, but not BDNF-TrkB or VEGF-VEGFR1, mediates endometriosis-associated pain. Moreover, entrectinib blocks endometriosis-associated pain and reduces lesion sizes. Our results also indicated that entrectinib-like molecules are promising candidates for endometriosis treatment.
Authors
- Allison F. Vitonis (ORCID: https://orcid.org/0000-0003-1243-0844)
- Stacey A. Missmer (ORCID: https://orcid.org/0000-0003-3147-6768)
- Olivia K. Heintz (ORCID: https://orcid.org/0009-0007-6946-0450)
- Michael S. Rogers (ORCID: https://orcid.org/0000-0002-5250-8434)
- Stephen K. Godin (ORCID: https://orcid.org/0000-0002-8726-3254)
- K. Wright (ORCID: https://orcid.org/0000-0003-2147-8778)
- Avacir Casanova Andrello (ORCID: https://orcid.org/0000-0001-6943-8973)
- Danielle Sim (ORCID: https://orcid.org/0000-0003-4131-9977)
- Dara Bree (ORCID: https://orcid.org/0000-0001-6935-9730)
- Hussain Bukhari (ORCID: https://orcid.org/0000-0001-7730-6399)
- Raymond M. Anchan (ORCID: https://orcid.org/0000-0002-9615-6477)
- Kathryn L. Terry (ORCID: https://orcid.org/0009-0002-5848-4661)
- Tiago H. Zaninelli (ORCID: https://orcid.org/0000-0001-7233-477X)
- Philip R. Bennallack (ORCID: https://orcid.org/0000-0001-7301-8576)
- Waldiceu Aparecido Verri Jr (ORCID: https://orcid.org/0000-0003-2756-9283)
- Victor Fattori (ORCID: https://orcid.org/0000-0002-4565-7706)
Institutions
- Universidade Estadual de Londrina (BR)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Cygnal Therapeutics (United States) (US)
- Michigan State University (US)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1016/j.jare.2024.08.017
- Citations
- 11
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.91
Funders
- J. Willard and Alice S. Marriott Foundation
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Estadual de Londrina