A new evaluation of the rearranged non-coding control region of JC virus in patients with colorectal cancer
A significant proportion of 35%> of the tumor tissue and urine samples of the CRC patients was found to be positive for JCV DNA (P = 0.25). The parallel analysis of tumor and urine samples for JCV DNA further supports the potential for non-invasive screening tools. This study provides new insights into Rearranged NCCR variant isolates from patients with CRC. The significant difference in JCV LTAg expression between tumor and normal tissue indicates a latent JCV status potentially leading to cancer development.
Authors
- Manoochehr Makvandi (ORCID: https://orcid.org/0000-0001-5602-6961)
- Shahram Jalilian (ORCID: https://orcid.org/0000-0002-1827-2990)
- Kambiz Ahmadi Angali (ORCID: https://orcid.org/0000-0002-1530-2349)
- Abdolhassan Talaiezadeh (ORCID: https://orcid.org/0000-0002-2346-505X)
- Azadeh Haghi Navand
- Mohammad Karimi Babaahmadi
Institutions
- Ahvaz Jundishapur University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12885-024-12684-x
- Citations
- 1
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- Ahvaz Jundishapur University of Medical Sciences