Exposure to doxycycline increases risk of carrying a broad range of enteric antimicrobial resistance determinants in an elderly cohort
The gut microbiome of aged care residents is a major reservoir of antibiotic resistance. As a critical antibiotic in medical practice, a comprehensive understanding of the impact of doxycycline exposure on the gut resistome is paramount for informed antibiotic use, particularly in an evolving landscape of prophylactic applications. Near-universal asymptomatic carriage of clinically critical resistance determinants is highly concerning and reinforces the urgent need for improved management of antibiotic use in long-term aged care.
Authors
- Erin Flynn (ORCID: https://orcid.org/0000-0002-7107-7641)
- Lito E. Papanicolas (ORCID: https://orcid.org/0000-0002-5838-7274)
- Andrew P. Shoubridge (ORCID: https://orcid.org/0000-0002-5148-4063)
- Maria Crotty (ORCID: https://orcid.org/0000-0002-2996-5135)
- David Gordon (ORCID: https://orcid.org/0000-0003-3276-9685)
- Kerry L. Ivey (ORCID: https://orcid.org/0000-0001-9855-2599)
- Jocelyn M. Choo (ORCID: https://orcid.org/0000-0001-9500-8360)
- Josephine Collins
- Sophie Miller (ORCID: https://orcid.org/0009-0003-3889-7941)
- Craig Whitehead (ORCID: https://orcid.org/0000-0001-5859-8314)
- Lucy Carpenter
- Lex E. X. Leong (ORCID: https://orcid.org/0000-0002-5073-2272)
- Steven Taylor (ORCID: https://orcid.org/0000-0003-4357-8243)
- Maria C. Inacio (ORCID: https://orcid.org/0000-0001-8261-2665)
- Steve Wesselingh (ORCID: https://orcid.org/0000-0001-5605-1147)
- David J. Lynn (ORCID: https://orcid.org/0000-0003-4664-1404)
- Geraint B. Rogers (ORCID: https://orcid.org/0000-0003-4054-1947)
Institutions
- South Australia Pathology (AU)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Flinders University (AU)
- University of South Australia (AU)
- Flinders Medical Centre (AU)
- SA Health (AU)
- South Australian Health and Medical Research Institute (AU)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1016/j.jinf.2024.106243
- Citations
- 11
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.87