Skeletal Reorganization: Approaches towards the Synthesis of Aza-Heterocyclic Cores

Abstract The impetuous development of the pharmaceutical industry and material science stimulates the search for new synthetic approaches and new methods for the synthesis and functionalization of aza-heterocycles; these are some of the key objectives of modern organic chemistry. As a result, an advanced method towards the synthesis of functionalized N-heterocycles that circumvents the limitations associated with traditional methods needs to be devised. In recent decades, rearrangement/reorganization reactions have emerged as a powerful tool for the efficient synthesis of the aza-heterocycle. In this illustration, we summarize some our recent efforts in the development of few complex aza-heterocyclic cores. 1 Introduction 2 Skeletal Rearrangement of Small Heterocycles via Domino Ring-Opening and Ring-Closing (DROC) Strategy 3 Ru(II)-Catalyzed Skeletal Rearrangement of the Quinazoline Ring 4 Lewis Acid Catalyzed Skeletal Rearrangement of Furans to Indolizine Cores 5 Skeletal Rearrangement of Donor–Acceptor Cyclopropanes via Domino Ring-Opening and Ring-Closing (DROC) Strategy 6 Lewis Acid Mediated Skeletal Rearrangement of Donor–Acceptor Spirocyclopropylpyrazolones 7 Skeletal Rearrangement through Ring Distortion Strategy 8 Conclusion