Skin microdialysis detects distinct immunologic patterns in chronic inflammatory skin diseases
On the basis of microdialysates, the proteomic data of lesional PSO and PN skin, but not lesional AD skin, differed significantly from those of nonlesional skin. IL-8, IL-22, MCP-1, and IL-12p40 might be suitable markers for minimally invasive molecular profiling.
Authors
- Anne Heetfeld
- Stephan Traidl (ORCID: https://orcid.org/0000-0003-4806-599X)
- Andreas Leha (ORCID: https://orcid.org/0000-0002-8072-1988)
- Timo Buhl (ORCID: https://orcid.org/0000-0002-3139-129X)
- Martin Steinhoff (ORCID: https://orcid.org/0000-0002-7090-2187)
- Moritz M. Hollstein (ORCID: https://orcid.org/0000-0003-0511-3445)
- Natalia Alkon (ORCID: https://orcid.org/0000-0002-0336-5318)
- Patrick M. Brunner (ORCID: https://orcid.org/0000-0002-3488-3345)
- Susann Forkel (ORCID: https://orcid.org/0000-0002-1106-2464)
- Christof Lenz (ORCID: https://orcid.org/0000-0002-0946-8166)
- Michael P. Schön (ORCID: https://orcid.org/0000-0002-0698-4130)
- Martin Schmelz (ORCID: https://orcid.org/0000-0002-9736-7241)
- Jannik Ruwisch (ORCID: https://orcid.org/0000-0003-1654-6668)
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Medizinische Hochschule Hannover (DE)
- Universitätsmedizin Göttingen (DE)
- Max Planck Institute for Biophysical Chemistry (DE)
- Max Planck Institute for Multidisciplinary Sciences (DE)
- Hamad Medical Corporation (QA)
- University of Göttingen (DE)
- Medical University of Vienna (AT)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1016/j.jaci.2024.06.024
- Citations
- 4
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.14
Funders
- Kiniksa Pharmaceuticals
- Deutsche Forschungsgemeinschaft