Fibrinolysis associated proteins and lipopolysaccharide bioactivity in plasma and cerebrospinal fluid in multiple sclerosis
The coagulation cascade and fibrinolysis have links with neuroinflammation and increased activation of the coagulation system has been reported in MS patients. We quantified levels of D-dimer, tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and the bioactivity of bacterial lipopolysaccharide (LPS) in cerebrospinal fluid (CSF) and plasma from newly diagnosed untreated MS patients and controls. These molecules showed multiple correlations with each other as well as with age, HLA-DRB1*15:01, body-mass-index and CSF IgG. Our results confirm previous findings of increased plasma PAI-1 and LPS in MS patients compared to controls indicating changes in platelet function and gut permeability in MS.
Authors
- Katariina Nurmi (ORCID: https://orcid.org/0000-0001-5406-5334)
- Antti Vaheri (ORCID: https://orcid.org/0000-0003-2670-2345)
- Joonas Lehikoinen (ORCID: https://orcid.org/0000-0002-6709-1563)
- J. Parantainen (ORCID: https://orcid.org/0000-0002-6791-198X)
- Tomas Strandin (ORCID: https://orcid.org/0000-0002-2454-7479)
- Francisco J. Rivera (ORCID: https://orcid.org/0000-0001-7895-6318)
- Kari K. Eklund (ORCID: https://orcid.org/0000-0002-5870-4663)
- Pentti J. Tienari (ORCID: https://orcid.org/0000-0001-5686-2900)
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
Publication Details
- Journal
- Journal of Neuroimmunology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1016/j.jneuroim.2024.578432
- Citations
- 5
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.27
Funders
- Biogen
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Academy of Finland
- Suomen Kulttuurirahasto
- Agencia Nacional de Investigación y Desarrollo
- Fondo Nacional de Desarrollo Científico y Tecnológico