An essential role of the E3 ubiquitin ligase RNF126 in ensuring meiosis I completion during spermatogenesis
Our findings demonstrate the pivotal role of RNF126 in maintaining spermatogenesis and fertility, offering insights into the molecular mechanisms underlying male infertility. The identified RNF126 variants present novel targets for diagnostic and therapeutic strategies in treating nonobstructive male infertility.
Authors
- Xiya Sun (ORCID: https://orcid.org/0009-0004-1934-8450)
- Fubing Li (ORCID: https://orcid.org/0000-0003-2848-015X)
- Zhiqiang Yan (ORCID: https://orcid.org/0000-0002-8658-4048)
- Ceshi Chen (ORCID: https://orcid.org/0000-0001-6398-3516)
- Tingyue Wu
- Yuxin Zhao (ORCID: https://orcid.org/0000-0003-1776-4173)
- Dewei Jiang (ORCID: https://orcid.org/0000-0002-7773-5449)
- Qiuyun Jiang (ORCID: https://orcid.org/0000-0003-3241-493X)
- Wenhui Li (ORCID: https://orcid.org/0000-0001-5874-0122)
- Rong Liu (ORCID: https://orcid.org/0000-0001-6123-9152)
- Wenjing Liu (ORCID: https://orcid.org/0000-0001-5081-9047)
- Yingying Wu (ORCID: https://orcid.org/0000-0003-3837-0050)
- Meng Qin (ORCID: https://orcid.org/0000-0003-3376-6822)
- Xu Zhi (ORCID: https://orcid.org/0000-0003-1177-0599)
- Jingyi Yang (ORCID: https://orcid.org/0000-0003-4640-664X)
- Jianting An
- Yongjia Tang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Kunming Institute of Zoology (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Peking University Third Hospital (CN)
- Center for Life Sciences (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1016/j.jare.2024.08.011
- Citations
- 5
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Tianjin Postdoctoral Science Foundation
- Lin He's New Medicine and Clinical Translation Academician Workstation Research Fund
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Kunming Medical University
- Natural Science Foundation of Beijing Municipality
- China West Normal University
- Yunnan Provincial Science and Technology Department
- National Aerospace Science Foundation of China
- Liaoning Revitalization Talents Program
- Beijing Municipal Natural Science Foundation
- National Key Clinical Specialty Discipline Construction Program of China
- Key Science and Technology Program of Shaanxi Province
- Major Science and Technology Projects in Yunnan Province
- Key Science and Technology Research Project in Jiangxi Province Department of Education