Berberine suppressed the epithelial–mesenchymal transition (EMT) of colon epithelial cells through the TGF-β1/Smad and NF-κB pathways associated with miRNA-1269a
BBR can significantly inhibit TGF-β1-induced EMT in normal and cancerous colon epithelial cells through the inhibition of the TGF-β1/Smad and NF-κB p65 pathways. TGF-β1/Smads can promote the NF-κB p65 pathway, which is a common target of miR-1269a, and can partially regulate the expression of miR-1269a.
Authors
- Weizeng Shen
- H.-L. Liu
- Chao Huang (ORCID: https://orcid.org/0000-0003-3371-6462)
- Yue He (ORCID: https://orcid.org/0000-0003-4737-343X)
- Yidian Yang
Institutions
- Shenzhen University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e36059
- Citations
- 6
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 2.69
Funders
- Natural Science Foundation of Shenzhen City
- Association of Medical Research Charities
- Shenzhen University