Palladium-Catalyzed Decarbonylative Michaelis–Arbuzov Reaction of Carboxylic Acids and Triaryl Phosphites
A Pd-catalyzed decarbonylative Michaelis-Arbuzov reaction of carboxylic acids and triaryl phosphites for preparing aryl phosphonates under anhydride-free conditions has been reported. In this context, triaryl phosphites serve as both reagents for activating the carboxylic acids and substrates for the reaction. There have been no reports to date of efficient and direct methods for the <i>in situ</i> activation of carboxylic acids using triaryl phosphites. In comparison to known methods, this reaction avoids the use of organohalides and has an excellent functional group tolerance for the synthesis of various aryl phosphonates from triaryl phosphites and carboxylic acids. This reaction is scalable and applicable to the synthesis of aryl phosphonates featuring bioactive fragments.
Authors
- Mengjie Cen
- Li‐Biao Han (ORCID: https://orcid.org/0000-0001-5566-9017)
- Zhixuan Xu (ORCID: https://orcid.org/0000-0001-7335-9717)
- Tianzeng Huang (ORCID: https://orcid.org/0000-0002-1568-0817)
- Bencan Tang (ORCID: https://orcid.org/0000-0002-4301-2496)
- Tieqiao Chen (ORCID: https://orcid.org/0000-0002-9787-9538)
- Linbin Yao (ORCID: https://orcid.org/0000-0002-6318-0526)
- Zihan Chen (ORCID: https://orcid.org/0009-0000-8910-8357)
- Long Liu (ORCID: https://orcid.org/0000-0002-6472-5057)
- Chunya Li (ORCID: https://orcid.org/0000-0002-4252-1002)
Institutions
- University of Nottingham Ningbo China (CN)
- Shaoxing University (CN)
- Hainan University (CN)
- Institute of New Materials (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1021/acs.orglett.4c02495
- Citations
- 4
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hainan Province