Copper‐Catalyzed Oxidative Intramolecular Cyclization for the Synthesis of 2‐Hydroxy‐Indolin‐3‐Ones
Abstract The synthesis of substituted 2‐hydroxy‐indolin‐3‐ones has attracted considerable attention due to the frequent presence of the indole nucleus in numerous natural products and biologically active molecules. Herein, a direct access to 2‐hydroxy‐indolin‐3‐ones through copper‐catalyzed oxidative intramolecular cyclization of N ‐(2‐acetylphenyl)picolinamide has been developed. This method exhibits good functional group tolerance, atom‐economy and avoids the pre‐functionalization of substrates.
Authors
- Fengyuan Zhou
- Yuqi Li (ORCID: https://orcid.org/0000-0003-1501-1549)
- Xing Yang (ORCID: https://orcid.org/0000-0001-5186-4990)
- Guosheng Huang (ORCID: https://orcid.org/0000-0002-3866-6241)
- Haojie Ma (ORCID: https://orcid.org/0000-0002-5604-7524)
- Ji‐Jiang Wang (ORCID: https://orcid.org/0000-0001-8423-5592)
- Yuqi Zhang (ORCID: https://orcid.org/0000-0001-9577-3150)
Institutions
- Chinese Academy of Sciences (CN)
- Lanzhou Institute of Chemical Physics (CN)
- Yan'an University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-08-11
- DOI
- https://doi.org/10.1002/adsc.202400493
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China
- Education Department of Shaanxi Province