The Impact of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn’s Disease
NETs potentially serve as an initial stimulus for pathological activation of fibroblasts within the intestine via the TLR2/NF-κB pathway. Given their early involvement in inflammation, inhibition of PAD4 might offer a strategy to modulate both inflammation and fibrogenesis in CD.
Authors
- Gert De Hertogh (ORCID: https://orcid.org/0000-0001-8494-7725)
- Tommaso Mello (ORCID: https://orcid.org/0000-0002-6192-6902)
- Stefano Scaringi (ORCID: https://orcid.org/0000-0002-6838-8318)
- Lucia Picariello
- Severine A.R.A. Vermeire (ORCID: https://orcid.org/0000-0001-9942-3019)
- Gabriele Bislenghi (ORCID: https://orcid.org/0000-0002-9212-9287)
- Andrea Galli (ORCID: https://orcid.org/0000-0001-5416-6290)
- Gianluca Matteoli (ORCID: https://orcid.org/0000-0002-2902-4976)
- Bram Verstockt (ORCID: https://orcid.org/0000-0003-3898-7093)
- Bo-Jun Ke
- Saeed Abdurahiman (ORCID: https://orcid.org/0000-0001-8936-7498)
- E. Ceni (ORCID: https://orcid.org/0000-0003-2156-3964)
- Stefano Milani (ORCID: https://orcid.org/0000-0002-1337-9107)
- Valérie Spalart (ORCID: https://orcid.org/0000-0002-4937-5810)
- Gabriele Dragoni (ORCID: https://orcid.org/0000-0001-5752-5113)
- Simone Polvani (ORCID: https://orcid.org/0000-0002-3707-1043)
- Tommaso Innocenti (ORCID: https://orcid.org/0000-0002-2154-0490)
- Francesca Biscu (ORCID: https://orcid.org/0000-0001-8191-8865)
- Kimberly Martinod (ORCID: https://orcid.org/0000-0002-1026-6107)
- André D’Hoore (ORCID: https://orcid.org/0000-0002-6978-809X)
Institutions
- VIB-KU Leuven Center for Cancer Biology (BE)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Centre for Inflammation Research (GB)
- University of Florence (IT)
- University of Edinburgh (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2024-08-10
- DOI
- https://doi.org/10.1093/ecco-jcc/jjae121
- Citations
- 10
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- European Crohn's and Colitis Organisation
- Fonds Wetenschappelijk Onderzoek