Quantitative proteomic analysis and replacement therapy identifies haptoglobin as a therapeutic target in a murine model of SLE-associated diffuse alveolar hemorrhage

A reduction in plasma Hp levels was observed in SLE-DAH, and the replacement therapy with Hp could alleviate pulmonary hemorrhage and reduce mortality in DAH mice. This study identified Hp as a potential biomarker for its clinical diagnosis and a direction for treatment.

Authors

Ninghui Yan
Chenyi Shao
Nana Xia
Xueliang Zhang (ORCID: https://orcid.org/0000-0002-6706-8830)
Qiang Guo (ORCID: https://orcid.org/0000-0002-0605-7804)
Zhen Yan (ORCID: https://orcid.org/0000-0003-0658-3019)

Institutions

Shanghai Jiao Tong University (CN)
Renji Hospital (CN)

Publication Details

Journal: Frontiers in Veterinary Science
Published: 2024-08-12
DOI: https://doi.org/10.3389/fvets.2024.1431738
Primary Topic: Erythrocyte Function and Pathophysiology
Type: article
Field-Weighted Citation Impact: 0.00

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article

Quantitative proteomic analysis and replacement therapy identifies haptoglobin as a therapeutic target in a murine model of SLE-associated diffuse alveolar hemorrhage

Ninghui Yan, Chenyi Shao, Nana Xia, Xueliang Zhang et al.

Aug 12, 2024

Frontiers in Veterinary Science

Erythrocyte Function and Pathophysiology

article

Quantitative proteomic analysis and replacement therapy identifies haptoglobin as a therapeutic target in a murine model of SLE-associated diffuse alveolar hemorrhage

Ninghui Yan, Chenyi Shao, Nana Xia, Xueliang Zhang, Qiang Guo, Zhen Yan

August 12, 2024article en

Abstract

A reduction in plasma Hp levels was observed in SLE-DAH, and the replacement therapy with Hp could alleviate pulmonary hemorrhage and reduce mortality in DAH mice. This study identified Hp as a potential biomarker for its clinical diagnosis and a direction for treatment.

Frontiers in Veterinary ScienceVol. 11

Shanghai Jiao Tong University (CN), Renji Hospital (CN)

Good health and well-being

Openalex Percentile: Top 82%

Erythrocyte Function and Pathophysiology

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Quantitative proteomic analysis and replacement therapy identifies haptoglobin as a therapeutic target in a murine model of SLE-associated diffuse alveolar hemorrhage — Ninghui Yan, Chenyi Shao, et al. · Frontiers in Veterinary Science (2024) | TGRS Research Map | TGRS