Whole exome sequencing analyses identified novel genes for Alzheimer's disease and related dementia
Gene-based analyses of rare variants identified five novel genes for Alzheimer's disease and related dementia (ADRD), including FRMD8, DDX1, DNMT3L, MORC1, and TGM2. Single-variant analyses of common variants identified two novel genes for ADRD, including SLCO1C1 and NDNF. The identified genes were predominantly enriched in amyloid-β process pathways, microglia, and brain regions like hippocampus. DDX1, DNMT3L, TGM2, SLCO1C1, and NDNF could be effective drug targets.
Authors
- Wei‐Shi Liu
- Jin‐Tai Yu (ORCID: https://orcid.org/0000-0002-7686-0547)
- Jianfeng Feng (ORCID: https://orcid.org/0000-0001-5987-2258)
- Wei Cheng (ORCID: https://orcid.org/0000-0001-5126-8929)
- Jujiao Kang (ORCID: https://orcid.org/0000-0002-4489-7281)
- Yue‐Ting Deng
- Yu Guo
- Shi‐Dong Chen
- Ya‐Ru Zhang
- Xinrui Wu (ORCID: https://orcid.org/0000-0002-5160-538X)
- Bang‐Sheng Wu (ORCID: https://orcid.org/0000-0002-8807-6354)
- Yang Liu (ORCID: https://orcid.org/0000-0001-5586-623X)
Institutions
- Zhejiang Normal University (CN)
- Fudan University (CN)
- University of Warwick (GB)
- Shanghai Institute for Science of Science (CN)
- Huashan Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- State Key Laboratory of Medical Neurobiology
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-11
- DOI
- https://doi.org/10.1002/alz.14181
- Citations
- 17
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- Shanghai Center for Brain Science and Brain-Inspired Technology
- National Natural Science Foundation of China
- Huashan Hospital
- Shanghai Rising-Star Program
- Higher Education Discipline Innovation Project