Clinical and cognitive outcomes in first-episode psychosis: focus on the interplay between cannabis use and genetic variability in endocannabinoid receptors

Despite the preliminary nature of the sample, our findings point towards the role of genetic variants at <i>CNR1</i> and <i>CNR2</i> genes in the severity of the disorganized symptoms of first-episode psychosis and modulating cognitive performance conditional to cannabis use. This highlights the need for further characterization of the combined role of endocannabinoid system genetic variability and cannabis use in the understanding of the pathophysiology of psychosis.

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Publication Details

Journal
Frontiers in Psychology
Published
2024-08-12
DOI
https://doi.org/10.3389/fpsyg.2024.1414098
Citations
1
Primary Topic
Cannabis and Cannabinoid Research
Type
article
Field-Weighted Citation Impact
0.45

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article

Clinical and cognitive outcomes in first-episode psychosis: focus on the interplay between cannabis use and genetic variability in endocannabinoid receptors

Edith Pomarol‐Clotet, Maitane Oscoz-Irurozqui, Salvador Sarró, Amalia Guerrero‐Pedraza et al.
1 citations
Frontiers in Psychology
Cannabis and Cannabinoid Research
0.45
article

Clinical and cognitive outcomes in first-episode psychosis: focus on the interplay between cannabis use and genetic variability in endocannabinoid receptors

Edith Pomarol‐Clotet, Maitane Oscoz-Irurozqui, Salvador Sarró, Amalia Guerrero‐Pedraza, Mar Fatjó‐Vilas, Carmen Almodóvar-Payá, María Isabel Huéscar Carrión, Noemí Hostalet, Maria Guardiola-Ripoll, JJ Gomar
article en
1 citations

Abstract

Despite the preliminary nature of the sample, our findings point towards the role of genetic variants at <i>CNR1</i> and <i>CNR2</i> genes in the severity of the disorganized symptoms of first-episode psychosis and modulating cognitive performance conditional to cannabis use. This highlights the need for further characterization of the combined role of endocannabinoid system genetic variability and cannabis use in the understanding of the pathophysiology of psychosis.

Frontiers in PsychologyVol. 15
Feinstein Institute for Medical Research (US), Instituto de Salud Carlos III (ES), Centro de Investigación Biomédica en Red de Salud Mental (ES), Centre for Biomedical Network Research on Rare Diseases (ES), Fidmag Sisters Hospitallers (ES), Osakidetza (ES), Diputación Foral de Gipuzkoa (ES), Hospital Universitario San Rafael (ES), Instituto de Investigación de Enfermedades Raras (ES), Universitat de Barcelona (ES)
Generalitat de Catalunya, Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III, European Regional Development Fund
Good health and well-being
Openalex Percentile: Top 33%
Cannabis and Cannabinoid Research
0.45
DOIOpen Access PDFOpenAlex
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