PITX2 deficiency leads to atrial mitochondrial dysfunction

PITX2 deficiency causes atrial mitochondrial dysfunction and a metabolic shift to glycolysis in human aCMs. PITX2-dependent metabolic changes can contribute to the structural and functional defects found in PITX2-deficient atria.

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Publication Details

Journal
Cardiovascular Research
Published
2024-08-12
DOI
https://doi.org/10.1093/cvr/cvae169
Citations
26
Primary Topic
Nuclear Receptors and Signaling
Type
article
Field-Weighted Citation Impact
6.98

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article

PITX2 deficiency leads to atrial mitochondrial dysfunction

Neil V. Morgan, S. Nashitha Kabir, Stéphane Hatem, Joris Winters et al.
26 citations
Cardiovascular Research
Nuclear Receptors and Signaling
6.98
article

PITX2 deficiency leads to atrial mitochondrial dysfunction

Neil V. Morgan, S. Nashitha Kabir, Stéphane Hatem, Joris Winters, Kristina Lorenz, Jonathan Barlow, Katja Gehmlich, Sönke Harder, Michaela Schweizer, Molly O’Reilly, Ellen Thiemann, Stefan Kääb, Stef Zeemering, Friederike Cuello, Abdullah O. Khan, Jasmeet S. Reyat, Ulrich Schotten, Paulus Kirchhof, Laura C. Sommerfeld, Christopher O’Shea, Larissa Fabritz, Theresa Brand, Lluı́s Mont, Norbert Hübner, Monika Stoll, Rachel J. Stapley, Victor Roth Cardoso, Olivia Grech, Julie Rayes, Oliver Hummel, Winnie Chua, Georgios V. Gkoutos, Angelika Piasecki, Christian Müller
article en
26 citations

Abstract

PITX2 deficiency causes atrial mitochondrial dysfunction and a metabolic shift to glycolysis in human aCMs. PITX2-dependent metabolic changes can contribute to the structural and functional defects found in PITX2-deficient atria.

Cardiovascular ResearchVol. 120(15)
Inserm (FR), Universität Hamburg (DE), Morpho (United States) (US), Max Delbrück Center (DE), University of Würzburg (DE), John Radcliffe Hospital (GB), Maastricht University (NL), Sorbonne Université (FR), University of Oxford (GB), University Medical Center Hamburg-Eppendorf (DE), Centro de Investigación Biomédica en Red (ES), Institute of Human Genetics (PL), Leibniz Institute for Analytical Sciences - ISAS (DE), Pitié-Salpêtrière Hospital (FR), Institute for Research in Biomedicine (ES), German Centre for Cardiovascular Research (DE), Cardiovascular Research Center (BR), Unité de recherche sur les maladies cardiovasculaires et métaboliques (FR), Genomics (United Kingdom) (GB), Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR), Institute of Pharmacology (CZ), Universitat de Barcelona (ES), Charité - Universitätsmedizin Berlin (DE), University of Birmingham (GB), Ludwig-Maximilians-Universität München (DE)
Deutsches Zentrum für Herz-Kreislaufforschung, UK Research and Innovation, British Heart Foundation, Department of Health and Social Care, University of Oxford, European Commission, University of Birmingham, Deutsche Forschungsgemeinschaft, Fondation Leducq, ZonMw, Hartstichting, Medical Research Council Canada, Medical Research Council
Good health and well-being
Openalex Percentile: Top 2%
Nuclear Receptors and Signaling
6.98
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