PITX2 deficiency leads to atrial mitochondrial dysfunction
PITX2 deficiency causes atrial mitochondrial dysfunction and a metabolic shift to glycolysis in human aCMs. PITX2-dependent metabolic changes can contribute to the structural and functional defects found in PITX2-deficient atria.
Authors
- Neil V. Morgan (ORCID: https://orcid.org/0000-0001-6433-5692)
- S. Nashitha Kabir (ORCID: https://orcid.org/0000-0003-1811-8683)
- Stéphane Hatem (ORCID: https://orcid.org/0000-0002-9790-0755)
- Joris Winters (ORCID: https://orcid.org/0000-0002-4945-3946)
- Kristina Lorenz (ORCID: https://orcid.org/0000-0002-5747-2207)
- Jonathan Barlow (ORCID: https://orcid.org/0000-0002-9463-7234)
- Katja Gehmlich (ORCID: https://orcid.org/0000-0003-4019-1844)
- Sönke Harder (ORCID: https://orcid.org/0000-0002-6352-4771)
- Michaela Schweizer (ORCID: https://orcid.org/0000-0001-5062-328X)
- Molly O’Reilly (ORCID: https://orcid.org/0000-0003-1936-5838)
- Ellen Thiemann
- Stefan Kääb (ORCID: https://orcid.org/0000-0001-8824-3581)
- Stef Zeemering (ORCID: https://orcid.org/0000-0003-3738-7328)
- Friederike Cuello (ORCID: https://orcid.org/0000-0003-1612-1715)
- Abdullah O. Khan (ORCID: https://orcid.org/0000-0003-0825-3179)
- Jasmeet S. Reyat (ORCID: https://orcid.org/0000-0003-3247-9186)
- Ulrich Schotten (ORCID: https://orcid.org/0000-0003-1532-3315)
- Paulus Kirchhof (ORCID: https://orcid.org/0000-0002-1881-0197)
- Laura C. Sommerfeld (ORCID: https://orcid.org/0000-0001-9837-8770)
- Christopher O’Shea (ORCID: https://orcid.org/0000-0003-3030-7364)
- Larissa Fabritz (ORCID: https://orcid.org/0000-0002-9241-1733)
- Theresa Brand
- Lluı́s Mont (ORCID: https://orcid.org/0000-0002-8115-5906)
- Norbert Hübner (ORCID: https://orcid.org/0000-0002-1218-6223)
- Monika Stoll (ORCID: https://orcid.org/0000-0002-2711-4281)
- Rachel J. Stapley (ORCID: https://orcid.org/0000-0002-0027-9158)
- Victor Roth Cardoso (ORCID: https://orcid.org/0000-0002-9588-6304)
- Olivia Grech (ORCID: https://orcid.org/0000-0001-5560-802X)
- Julie Rayes (ORCID: https://orcid.org/0000-0003-0499-6880)
- Oliver Hummel (ORCID: https://orcid.org/0009-0000-9986-8333)
- Winnie Chua (ORCID: https://orcid.org/0000-0002-6747-8813)
- Georgios V. Gkoutos (ORCID: https://orcid.org/0000-0002-2061-091X)
- Angelika Piasecki
- Christian Müller
Institutions
- Inserm (FR)
- Universität Hamburg (DE)
- Morpho (United States) (US)
- Max Delbrück Center (DE)
- University of Würzburg (DE)
- John Radcliffe Hospital (GB)
- Maastricht University (NL)
- Sorbonne Université (FR)
- University of Oxford (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- Centro de Investigación Biomédica en Red (ES)
- Institute of Human Genetics (PL)
- Leibniz Institute for Analytical Sciences - ISAS (DE)
- Pitié-Salpêtrière Hospital (FR)
- Institute for Research in Biomedicine (ES)
- German Centre for Cardiovascular Research (DE)
- Cardiovascular Research Center (BR)
- Unité de recherche sur les maladies cardiovasculaires et métaboliques (FR)
- Genomics (United Kingdom) (GB)
- Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR)
- Institute of Pharmacology (CZ)
- Universitat de Barcelona (ES)
- Charité - Universitätsmedizin Berlin (DE)
- University of Birmingham (GB)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1093/cvr/cvae169
- Citations
- 26
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 6.98
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- UK Research and Innovation
- British Heart Foundation
- Department of Health and Social Care
- University of Oxford
- European Commission
- University of Birmingham
- Deutsche Forschungsgemeinschaft
- Fondation Leducq
- ZonMw
- Hartstichting
- Medical Research Council Canada
- Medical Research Council