Neuronal repair after spinal cord injury by in vivo astrocyte reprogramming mediated by the overexpression of NeuroD1 and Neurogenin-2
The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord after spinal cord injury can reprogram astrocytes into neurons and significantly enhance cell regeneration at the injury site. The reprogramming of astrocytes can lead to tissue repair, thus improving the reduced threshold and increasing voluntary movements. This strategy can also improve the integrity of the blood-spinal cord barrier and enhance nerve conduction function. However, the simple reprogramming of astrocytes cannot lead to significant improvements in the striding function of the lower limbs.
Authors
- Huayong Du
- Wubo Liu (ORCID: https://orcid.org/0000-0002-7233-9519)
- Zuliyaer Talifu
- Xin Ping Xu (ORCID: https://orcid.org/0000-0002-6324-5211)
- Han Ke
- Yingli Jing
- Feng Gao (ORCID: https://orcid.org/0000-0002-4902-7429)
- Chunjia Zhang
- Jianjun Li (ORCID: https://orcid.org/0000-0003-2663-5971)
- Xiaoxin Wang (ORCID: https://orcid.org/0000-0003-1282-8481)
- Zehui Li (ORCID: https://orcid.org/0000-0003-2354-5356)
- Degang Yang (ORCID: https://orcid.org/0000-0002-2212-6793)
- Liangjie Du
- Yunzhu Pan (ORCID: https://orcid.org/0000-0001-5505-5031)
- Yan Yu
Institutions
- Shandong University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- China Rehabilitation Research Center (CN)
- Chinese Institute for Brain Research (CN)
- CRRC (China) (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Biological Research
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s40659-024-00534-w
- Citations
- 8
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 2.15