The downregulation of tight junction proteins and pIgR in the colonic epithelium causes the susceptibility of EpCAM+/− mice to colitis and gut microbiota dysbiosis
In conclusion, the heterozygous mutation of EpCAM increased the susceptibility to colitis, gut microbiota dysbiosis and liver injury.
Authors
- Huijuan Wu (ORCID: https://orcid.org/0000-0003-4681-4440)
- Zili Lei (ORCID: https://orcid.org/0000-0001-6832-3939)
- Wanwan Liu (ORCID: https://orcid.org/0000-0002-1198-6085)
- Ya Nie
- Jiao Guo (ORCID: https://orcid.org/0000-0002-0050-5055)
- Yanhong Yang (ORCID: https://orcid.org/0000-0002-3923-5523)
- Qing Hu (ORCID: https://orcid.org/0000-0001-8067-6569)
- Guibin Chen (ORCID: https://orcid.org/0000-0001-5520-1780)
- Ting Lin
- Li Huang
- Cunjie Kong
Institutions
- Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2024-08-12
- DOI
- https://doi.org/10.3389/fmolb.2024.1442611
- Citations
- 7
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.73