Dual targeting chimeric antigen receptor cells enhance antitumour activity by overcoming T cell exhaustion in pancreatic cancer
The dual-targeted CAR-T cells obtained enhancement of T effector function, inhibition of T cell exhaustion, and improvement of tumour microenvironment. Our findings provide a theoretical rationale for dual-targeted FAP/CLDN 18.2 CAR-T cells therapy in PDAC.
Authors
- Zonghai Li (ORCID: https://orcid.org/0000-0003-2448-3636)
- Dong Yiwei (ORCID: https://orcid.org/0000-0002-6162-9617)
- Ruixin Sun (ORCID: https://orcid.org/0000-0002-2096-8946)
- Hua Jiang (ORCID: https://orcid.org/0000-0002-4552-0785)
- Yansha Sun
- Min Zhou (ORCID: https://orcid.org/0000-0003-3756-4953)
- Bizhi Shi
- HU Xiao-li
- Liu Yifan
Institutions
- Tongji University (CN)
- Renji Hospital (CN)
- Shanghai Cancer Institute (CN)
- Tongji Hospital (CN)
- Regend Therapeutics (China) (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-08-11
- DOI
- https://doi.org/10.1111/bph.16505
- Citations
- 12
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.39
Funders
- National Natural Science Foundation of China
- Shanghai Municipal Health and Family Planning Commission