Baseline neutrophil-to-eosinophil-ratio and outcome in metastatic clear-cell renal cell carcinoma treated with nivolumab or ipilimumab/nivolumab
Lower baseline NER is associated with better PFS and OS, independent of IMDC risk score, in m-ccRCC patients treated with ipilimumab/nivolumab or nivolumab. It correlates with intratumoural molecular features possibly associated with better outcome on immune checkpoint inhibitors. The predictive power of this biomarker is probably limited and insufficient for patient selection.
Authors
- Eduard Roussel (ORCID: https://orcid.org/0000-0002-7835-5536)
- Liesbeth De Wever
- Yana Beulque
- Benoit Beuselinck (ORCID: https://orcid.org/0000-0001-7427-9102)
- Yannick Van Herck (ORCID: https://orcid.org/0000-0003-4604-8010)
- Annouschka Laenen
- Gabrielle Couchy
- Agnieszka Woźniak (ORCID: https://orcid.org/0000-0001-9726-144X)
- Jessica Zucman‐Rossi (ORCID: https://orcid.org/0000-0002-5687-0334)
- Marcella Baldewijns (ORCID: https://orcid.org/0000-0002-0882-2944)
- Abhishek D. Garg (ORCID: https://orcid.org/0000-0002-9976-9922)
- Philip R. Debruyne (ORCID: https://orcid.org/0000-0001-5438-9697)
- Lisa Kinget (ORCID: https://orcid.org/0000-0002-7479-4793)
- Lorenz Haaker (ORCID: https://orcid.org/0000-0002-4707-7641)
- Maarten Albersen (ORCID: https://orcid.org/0000-0002-6763-6586)
- Sajedeh Mobaraki
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Génomique Fonctionnelle des Tumeurs Solides (FR)
- Gilead Sciences (United States) (US)
- AZ Sint-Lucas (BE)
- Anglia Ruskin University (GB)
- University of Plymouth (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Acta Oncologica
- Published
- 2024-08-11
- DOI
- https://doi.org/10.2340/1651-226x.2024.40390
- Citations
- 4
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.68