Multimodal pulmonary clearance kinetics of carbon black nanoparticles deposited in the lungs of rats: the role of alveolar macrophages
This result highlights that the prolonged retention of poorly soluble NPs in the lung until day 28 is mediated by the phagocytosis of AMs, and the fast clearance between days 28-60 is due to the turnover time of AMs, estimated around 1-2 months after birth. Similarly, new generations of AMs mediate the slow phase between days 60 and 90. However, further studies are needed to understand the multimodal clearance mechanism and the modulation of pulmonary clearance of poorly soluble NPs.
Authors
- Kyuhong Lee (ORCID: https://orcid.org/0000-0003-4123-341X)
- Wan‐Seob Cho (ORCID: https://orcid.org/0000-0002-5254-8946)
- Muthuchamy Maruthupandy (ORCID: https://orcid.org/0000-0002-5084-8312)
- Gyuri Kim (ORCID: https://orcid.org/0000-0002-2242-2816)
- Dong-Keun Lee (ORCID: https://orcid.org/0000-0002-4952-8004)
Institutions
- Korea Institute of Toxicology (KR)
- Dong-A University (KR)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12989-024-00591-9
- Citations
- 12
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- National Research Foundation
- Ministry of Food and Drug Safety
- National Research Foundation of Korea
- National Institute of Food and Drug Safety Evaluation