KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement
Our study showed that the PDLSCs modulated osteoclastogenesis and increased the RANKL/OPG ratio under mechanical force through the KAT6A/YAP/TEAD4 pathway. KAT6A might be a novel target to accelerate OTM.
Authors
- Jiayi Wang (ORCID: https://orcid.org/0000-0001-9255-9079)
- Yunfei Zheng (ORCID: https://orcid.org/0000-0003-1899-8051)
- Weiran Li (ORCID: https://orcid.org/0000-0001-9895-1143)
- Xinyu Su
- Kuang Tan (ORCID: https://orcid.org/0000-0002-6889-1108)
Institutions
- King University (US)
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Progress in Orthodontics
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s40510-024-00530-6
- Citations
- 10
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 3.26
Funders
- National Natural Science Foundation of China