An Infrequent Histopathological Diagnosis in a Prevalent Systemic Disease: A Case of Renal Sarcoidosis

Sarcoidosis is a multisystemic granulomatous disease that results from an aberrant immunological response to certain antigens. Although pulmonary involvement predominates, renal involvement may also occur. We present the case of a 59-year-old woman with a recent diagnosis of hepatic sarcoidosis and a history of non-compliance with treatment who was admitted to the hospital for study of acute kidney injury. Renal dysfunction was assumed to be a result of acute interstitial nephritis, as revealed on renal biopsy, and alterations in glomerular hemodynamics due to hypercalcemia. Renal function recovered and serum calcium levels normalized with the introduction of corticosteroid therapy.

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Journal
Cureus
Published
2024-08-11
DOI
https://doi.org/10.7759/cureus.66633
Primary Topic
Sarcoidosis and Beryllium Toxicity Research
Type
article
Field-Weighted Citation Impact
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article

An Infrequent Histopathological Diagnosis in a Prevalent Systemic Disease: A Case of Renal Sarcoidosis

Marta Cocco da Costa, Nélson Domingues, Ana Cunha Rodrigues, José Luís Melo Pereira et al.
Cureus
Sarcoidosis and Beryllium Toxicity Research
article

An Infrequent Histopathological Diagnosis in a Prevalent Systemic Disease: A Case of Renal Sarcoidosis

Marta Cocco da Costa, Nélson Domingues, Ana Cunha Rodrigues, José Luís Melo Pereira, Sónia Reis Santos
article en

Abstract

Sarcoidosis is a multisystemic granulomatous disease that results from an aberrant immunological response to certain antigens. Although pulmonary involvement predominates, renal involvement may also occur. We present the case of a 59-year-old woman with a recent diagnosis of hepatic sarcoidosis and a history of non-compliance with treatment who was admitted to the hospital for study of acute kidney injury. Renal dysfunction was assumed to be a result of acute interstitial nephritis, as revealed on renal biopsy, and alterations in glomerular hemodynamics due to hypercalcemia. Renal function recovered and serum calcium levels normalized with the introduction of corticosteroid therapy.

CureusVol. 16(8)
Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
Openalex Percentile: Top 82%
Sarcoidosis and Beryllium Toxicity Research
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