DESIGN, PREPARE AND IN VITRO EVALUATION OF SOLID LIPID NANOPARTICLES LOADED CISPLATIN

The aim of this study was to investigate the effectiveness of a strategy based on the development of solid lipid Nanoparticles as an innovative formulation of Cisplatin with improved therapeutic efficacy.Cisplatin SLNs were prepared by Solvent evaporation method.The solubility of drug in different solid lipids was measured.FTIR studies indicated no interaction between drug and lipid.SLN were characterized for particle size, zeta potential, entrapment efficiency and surface morphology.In vitro drug release studies were performed in phosphate buffer of pH 7.4 using dialysis bag diffusion technique.The F5 formulation had shown maximum entrapment up to 88.90 % and sustained drug release for 8 h.The scanning electron microscopy and zeta potential study showed formation of good SLN dispersion.In vitro release profiles were biphasic in nature and followed Higuchi model of release kinetics.The stability study showed successful formation of stable SLNs.