Aqueous humor cytokine levels in patients with subretinal fibrosis in neovascular age-related macular degeneration
VEGF and bFGF levels in aqueous humor were elevated in macular neovascularization with and without subretinal fibrosis. TGF-α levels exclusively differed in neovascular AMD with fibrosis. Cytokines are distributed differently and play a synergistic role in different stages (angiogenesis and fibrogenesis) of nAMD. The bFGF levels could predict the negative prognosis in fibrosis due to nAMD.
Authors
- Lihua Hou (ORCID: https://orcid.org/0000-0003-3644-2612)
- Meijia Dang
- Shu-Hui Xing
- Jing Li (ORCID: https://orcid.org/0000-0003-1191-9971)
- Min Wang (ORCID: https://orcid.org/0000-0002-3420-4031)
- Tiantian Zhang (ORCID: https://orcid.org/0000-0002-8591-2652)
- Yingni Huang
- Zhen Tian (ORCID: https://orcid.org/0009-0008-9750-135X)
- Ying Cao (ORCID: https://orcid.org/0009-0004-0303-9995)
Institutions
- Shanxi Medical University (CN)
- Northwest University (CN)
- Xi'an Medical University (CN)
- Xian Yang Central Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
- Northwest University First Hospital
Publication Details
- Journal
- BMC Ophthalmology
- Published
- 2024-08-11
- DOI
- https://doi.org/10.1186/s12886-024-03614-3
- Citations
- 3
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- Natural Science Foundation of Shaanxi Province