The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta
Our results indicate that CA140 improves neuronal/synaptic/cognitive function and ameliorates Aβ/tau pathology and neuroinflammation by modulating DRD1 signaling in primary hippocampal neurons, primary astrocytes/microglia, WT mice, and aged 5xFAD mice.
Authors
- Geoffray Leriche (ORCID: https://orcid.org/0000-0003-2293-9273)
- Ha-Eun Lee (ORCID: https://orcid.org/0000-0002-4694-4889)
- Rachel S. Ehrlich
- Jerry Yang (ORCID: https://orcid.org/0000-0002-8423-7376)
- Jae‐Ick Kim (ORCID: https://orcid.org/0000-0001-9705-0394)
- Yoo Joo Jeong
- Hye Yun Kim (ORCID: https://orcid.org/0000-0003-3757-5652)
- Sehyun Chae (ORCID: https://orcid.org/0000-0001-6904-0623)
- Yuxi Lin (ORCID: https://orcid.org/0000-0002-5936-0954)
- Hyang‐Sook Hoe (ORCID: https://orcid.org/0000-0001-8877-8594)
- Sascha Castro Lingl
- Hyunju Lee (ORCID: https://orcid.org/0000-0003-0107-0724)
- Ji‐Eun Kim (ORCID: https://orcid.org/0000-0003-4709-262X)
- Young‐Ho Lee (ORCID: https://orcid.org/0000-0001-8238-2345)
- Min-Duk Seo
Institutions
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- University of California San Diego (US)
- Korea Basic Science Institute (KR)
- Korea Brain Research Institute (KR)
- Ulsan National Institute of Science and Technology (KR)
- Ajou University (KR)
- Chung-Ang University (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-08-11
- DOI
- https://doi.org/10.1186/s12974-024-03180-x
- Citations
- 17
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.68
Funders
- Korea Brain Research Institute
- National Research Foundation
- Korea Basic Science Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea