Intracellular Construction of Topological Polymer Networks to Destruct Organelles

Open AccessCCS ChemistryRESEARCH ARTICLES11 Aug 2024Intracellular Construction of Topological Polymer Networks to Destruct Organelles Chengfei Liu, Banruo Xianyu, Chaowei He, Muqing Cao, Zhuolin Chen, Tianyu Li and Huaping Xu Chengfei Liu , Banruo Xianyu , Chaowei He , Muqing Cao , Zhuolin Chen , Tianyu Li and Huaping Xu Cite this: CCS Chemistry. 2024;0:1–28https://doi.org/10.31635/ccschem.024.202404842 SectionsSupplemental MaterialAboutPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked InEmail Topological polymers play major roles in their interactions with intracellular organelles to affect the cellular activities owing to the large surface area and multilevel branched structures. Yet, the existing studies mainly focus on the topochemical polymerization outside the cells and how these topological polymers interact with the cell outer membrane. Herein, we established an intracellular topological polymerization based on the 2′-Te modified oligonucleotides (DNA-Te2), containing two tellurium as polymerization active sites and undergoing oxidative polymerization inside living cells. The highly oxidized polytelluoxane could effectively disturb antioxidant systems by an interaction between Te (IV) and selenoproteins, thus leading to the effective inhibition capacity to cancer cells. More importantly, the generated topological polymer networks are shown to interfere with organelles in cells, effectively affecting the substrate communication between organelles and the cytoplasm, eventually modulating the cellular behavior to kill cancer cells. Biological evaluation showed that our strategy exhibited efficient tumor inhibition effect and good biosafety. Ultimately, we believe our approach provides a new possibility for chemists and biologists to manipulate the cellular activity in the realm of topological polymerization. Download figure Download PowerPoint Previous articleNext article FiguresReferencesRelatedDetails Issue AssignmentNot Yet AssignedSupporting Information Copyright & Permissions© 2024 Chinese Chemical Society Downloaded 15 times PDF downloadLoading ...