Diet modifies the association between alcohol consumption and severe alcohol-related liver disease incidence

It is elusive why some heavy drinkers progress to severe alcohol-related liver disease (ALD) while others do not. This study aimed to investigate if the association between alcohol consumption and severe ALD is modified by diet. This prospective study included 303,269 UK Biobank participants. Alcohol consumption and diet were self-reported. The diet score was created from 4 items selected using LASSO. Cox proportional hazard model showed that the diet score was monotonically associated with severe ALD risk, adjusted for sociodemographics, lifestyle factors, and alcohol consumption. Relative excess risk due to interaction analysis indicated that having a higher ALD diet score and a higher alcohol consumption simultaneously confers to 2.44 times (95% CI: 1.06-3.83) higher risk than the sum of excess risk of each factor. In this work, we show that people who have a poor diet might be more susceptible to severe ALD due to alcohol consumption.

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Publication Details

Journal
Nature Communications
Published
2024-08-11
DOI
https://doi.org/10.1038/s41467-024-51314-9
Citations
13
Primary Topic
Alcohol Consumption and Health Effects
Type
article
Field-Weighted Citation Impact
5.52

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article

Diet modifies the association between alcohol consumption and severe alcohol-related liver disease incidence

David Raubenheimer, Fanny Petermann‐Rocha, Ewan H. Forrest, Jill P. Pell et al.
13 citations
Nature Communications
Alcohol Consumption and Health Effects
5.52
article

Diet modifies the association between alcohol consumption and severe alcohol-related liver disease incidence

David Raubenheimer, Fanny Petermann‐Rocha, Ewan H. Forrest, Jill P. Pell, Ziyi Zhou, John C. Mathers, Carlos Celis‐Morales, Naveed A. Sattar, Frederick K. Ho
article en
13 citations

Abstract

It is elusive why some heavy drinkers progress to severe alcohol-related liver disease (ALD) while others do not. This study aimed to investigate if the association between alcohol consumption and severe ALD is modified by diet. This prospective study included 303,269 UK Biobank participants. Alcohol consumption and diet were self-reported. The diet score was created from 4 items selected using LASSO. Cox proportional hazard model showed that the diet score was monotonically associated with severe ALD risk, adjusted for sociodemographics, lifestyle factors, and alcohol consumption. Relative excess risk due to interaction analysis indicated that having a higher ALD diet score and a higher alcohol consumption simultaneously confers to 2.44 times (95% CI: 1.06-3.83) higher risk than the sum of excess risk of each factor. In this work, we show that people who have a poor diet might be more susceptible to severe ALD due to alcohol consumption.

Nature CommunicationsVol. 15(1)
The University of Sydney (AU), Catholic University of the Maule (CL), Glasgow Royal Infirmary (GB), University of Glasgow (GB), Newcastle University (GB), Universidad Diego Portales (CL), Arturo Prat University (CL)
Wellcome Trust, British Heart Foundation, Northwest Regional Development Agency, Medical Research Council
Good health and well-being
Openalex Percentile: Top 4%
Alcohol Consumption and Health Effects
5.52
DOIOpen Access PDFOpenAlex
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