Single-cell transcriptomic analysis reveals a decrease in the frequency of macrophage-RGS1high subsets in patients with osteoarticular tuberculosis
The macrophage-RGS1<sup>high</sup> subset levels were decreased in patients with OTB, and would be up-regulated after effective treatment. Therefore, the clinical significance of this study is to discover that macrophage-RGS1<sup>high</sup> subset may serve as a potential biomarker for OTB diagnosis and treatment efficacy monitoring.
Authors
- Xinqiang Zhang (ORCID: https://orcid.org/0009-0004-4843-2627)
- Hong Lei (ORCID: https://orcid.org/0009-0004-6116-4196)
- Liping Tang (ORCID: https://orcid.org/0000-0002-9757-7548)
- Huicheng Feng
- Ying Jiang (ORCID: https://orcid.org/0000-0002-2644-3964)
- Bo Wang
- Di Wang (ORCID: https://orcid.org/0000-0003-0870-2157)
- Xin Liu (ORCID: https://orcid.org/0000-0003-4083-4731)
- Xiudong Ding
- Yueming Dong (ORCID: https://orcid.org/0000-0001-8897-128X)
Institutions
- Chinese PLA General Hospital (CN)
- Affiliated Hospital of Chengde Medical College (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-08-10
- DOI
- https://doi.org/10.1186/s10020-024-00886-9
- Citations
- 5
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- National Natural Science Foundation of China