Joint use of population pharmacokinetics and machine learning for prediction of valproic acid plasma concentration in elderly epileptic patients
Our model was specifically tailored for elderly epileptic patients, providing an efficient and cost-effective approach to predict VPA plasma concentration. The model combined classical PPK with machine learning, and underwent optimization through feature selection and algorithm integration. Our model can serve as a fundamental tool for clinicians in determining VPA plasma concentration and individualized dosing regimens accordingly.
Authors
- Hongfan Yu (ORCID: https://orcid.org/0000-0003-3167-1491)
- Xiao Qin (ORCID: https://orcid.org/0000-0003-0073-3485)
- Yuxian Nie (ORCID: https://orcid.org/0000-0003-4456-9832)
- Qiuling Shi (ORCID: https://orcid.org/0000-0003-0660-3809)
- Airong Yu (ORCID: https://orcid.org/0000-0001-8254-1051)
- Shenglan Shang (ORCID: https://orcid.org/0000-0002-2771-6100)
- Mengchen Yu (ORCID: https://orcid.org/0009-0003-1260-985X)
- Ruixiang Liu (ORCID: https://orcid.org/0009-0007-0779-4535)
- Zhou Fan (ORCID: https://orcid.org/0000-0003-3067-3540)
- Pan Ma (ORCID: https://orcid.org/0000-0002-0121-0769)
- Yifan Huang (ORCID: https://orcid.org/0000-0001-9646-1298)
- Qianxue Ding
- Ying Zhang (ORCID: https://orcid.org/0009-0001-5180-3829)
- Yongchuan Chen (ORCID: https://orcid.org/0000-0002-5999-2986)
- Zhibiao Wang
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Central Hospital of Wuhan (CN)
- Chongqing Public Health Medical Center (CN)
- General Hospital of Central Theater Command
- Chongqing Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2024-08-10
- DOI
- https://doi.org/10.1016/j.ejps.2024.106876
- Citations
- 7
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.76
Funders
- Tianjin Postdoctoral Science Foundation
- Chongqing Medical University
- Central Subordinate University Basic Scientific Research Foundation