Efficacy of pentoxifylline for the treatment of bipolar I/II patients with treatment-resistant depression: A proof-of-concept, randomized, double-blind, placebo-controlled trial

The current proof of concept study found that in terms of overall anti-depressant effectiveness in bipolar patients with TRD, PTX is not superior to placebo. However, it may improve depressive mood in a subpopulation of subjects with a higher pretreatment inflammatory profile.

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Publication Details

Journal
Brain Research Bulletin
Published
2024-08-10
DOI
https://doi.org/10.1016/j.brainresbull.2024.111047
Citations
8
Primary Topic
Bipolar Disorder and Treatment
Type
article
Field-Weighted Citation Impact
3.08
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article

Efficacy of pentoxifylline for the treatment of bipolar I/II patients with treatment-resistant depression: A proof-of-concept, randomized, double-blind, placebo-controlled trial

Teshk Shawis, Tavgah Ahmed Merza Mohammad, Talar Ahmed Merza Mohammad
8 citations
Brain Research Bulletin
Bipolar Disorder and Treatment
3.08
article

Efficacy of pentoxifylline for the treatment of bipolar I/II patients with treatment-resistant depression: A proof-of-concept, randomized, double-blind, placebo-controlled trial

Teshk Shawis, Tavgah Ahmed Merza Mohammad, Talar Ahmed Merza Mohammad
article en
8 citations

Abstract

The current proof of concept study found that in terms of overall anti-depressant effectiveness in bipolar patients with TRD, PTX is not superior to placebo. However, it may improve depressive mood in a subpopulation of subjects with a higher pretreatment inflammatory profile.

Brain Research BulletinVol. 216
Hawler Medical University (IQ), University of Kurdistan Hewler (IQ), University of Sulaimani (IQ)
Good health and well-being
Openalex Percentile: Top 7%
Bipolar Disorder and Treatment
3.08
DOIOpen Access PDFOpenAlex
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Efficacy of pentoxifylline for the treatment of bipolar I/II patients with treatment-resistant depression: A proof-of-concept, randomized, double-blind, placebo-controlled trial — Teshk Shawis, Tavgah Ahmed Merza Mohammad, et al. · Brain Research Bulletin (2024) | TGRS Research Map | TGRS