Advances in anti-aging research of urine-derived stem cells

Aging is a complex biological process characterized by the gradual decline in physiological functions, increasing the susceptibility to various age-related diseases. Recent advancements in regenerative medicine have highlighted the potential of stem cells in combating the effects of aging and treating age-related diseases. Among these, urine-derived stem cells (USCs) have emerged as a promising and non-invasive source of multipotent cells capable of differentiating into various cell types. This review aims to discuss the recent progress in the application of USCs in treating age-related diseases. We focused on the unique properties of USCs, including their ease of collection, high proliferation rate, and pluripotent differentiation potential. Furthermore, we summarized the mechanisms underlying the aging, so as to help understand the process of aging and the potential mechanisms through which USCs exert their anti-aging effects. Besides, we examined preclinical and clinical studies that demonstrate the therapeutic efficacy of USCs in treating age-related diseases such as neurodegenerative disorders, cardiovascular diseases, and musculoskeletal degenerations. This comprehensive review underscored the significant potential of USCs as a novel therapeutic strategy for aging and managing age-associated diseases.