Hyperglycemia‐induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis
Hyperglycemia induces metabolic reprogramming and inflammatory activation in microglia through the regulation of Sirt3 transcription and degradation. This novel mechanism identifies Sirt3 as a potential drug target for treating DNP.
Authors
- Mengqiu Deng
- Dashuang Chen
- Chaofeng Han (ORCID: https://orcid.org/0000-0002-8489-6478)
- Erliang Kong (ORCID: https://orcid.org/0000-0002-4036-6328)
- Ruitong Chu
- Honghao Song (ORCID: https://orcid.org/0009-0001-9838-5273)
- Hongbin Yuan (ORCID: https://orcid.org/0000-0001-8468-4005)
- Mei Yang (ORCID: https://orcid.org/0000-0003-4357-9000)
- Ruifeng Ding (ORCID: https://orcid.org/0000-0002-9874-8038)
- Hao‐Wei Wang (ORCID: https://orcid.org/0000-0002-5408-9253)
- Ping Zhang (ORCID: https://orcid.org/0000-0003-0858-8884)
- Jinfang Lu
- Huawei Wei (ORCID: https://orcid.org/0000-0002-4010-1792)
- Yongchang Li (ORCID: https://orcid.org/0000-0003-4589-0062)
- Hua Tong (ORCID: https://orcid.org/0000-0002-2581-6044)
Institutions
- Shanghai Changzheng Hospital (CN)
- People's Liberation Army 401 Hospital (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/cns.14913
- Citations
- 23
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 7.92
Funders
- National Natural Science Foundation of China