Porcine beta defensin 2 attenuates inflammatory responses in IPEC-J2 cells against Escherichia coli via TLRs-NF-κB/MAPK signaling pathway
pBD2 could reduce the inflammatory response induced by E. coli perhaps by inhibiting the TLRs-TAK1-NF-κB/MAPK signaling pathway which was activated by E. coli in IPEC-J2 cells. Our study further reveals the immunomodulatory activity of recombinant pBD2 against E. coli, and provides insights into the molecular mechanisms that protect cells from E. coli infection.
Authors
- Hanfang Cai (ORCID: https://orcid.org/0000-0002-6582-3476)
- Fengting Zhan
- Xiaoyang Shen
- Kejun Wang (ORCID: https://orcid.org/0000-0003-4337-980X)
- Kun Zhang (ORCID: https://orcid.org/0000-0001-5696-2426)
- Chunli Li (ORCID: https://orcid.org/0000-0002-9071-161X)
- Mingke Gu
Institutions
- Henan Institute of Science and Technology (CN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2024-08-10
- DOI
- https://doi.org/10.1186/s12917-024-04220-7
- Citations
- 7
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- Natural Science Foundation of Henan Province