Autophagy-enabled protein degradation: Key to platelet activation and ANGII production in patients with type 2 diabetes mellitus
In platelets, macroautophagy promotes protein digestion, subsequently facilitating platelet activation, ANGII-mediated vasoconstriction, and microthrombosis. Our results suggested that lysosome is a promising therapeutic target for antithrombotic treatment in T2DM.
Authors
- Shufei Zang (ORCID: https://orcid.org/0000-0003-0810-7649)
- Qiang Wu (ORCID: https://orcid.org/0009-0006-3713-7205)
- Kangkang Peng
- Zhicheng Wang
- Siwen Yu
Institutions
- Fudan University (CN)
- Songjiang District Central Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e36131
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.16