Influence of genetic co‐mutation on chemotherapeutic outcome in <i>NPM1</i>‐mutated and <i>FLT3‐ITD</i> wild‐type AML patients
Mutations in TET1/2, GATA2 and MDS-related genes were found to significantly influence the chemotherapeutic outcome of patients with NPM1<sup>mut</sup> AML. The findings of our study have significant clinical implications for identifying patients who have an adverse response to frontline chemotherapy and provide a novel reference for further prognostic stratification of NPM1<sup>mut</sup>/FLT3-ITD<sup>wt</sup> AML patients.
Authors
- Yun Huang (ORCID: https://orcid.org/0000-0002-3064-6641)
- Qian Wu (ORCID: https://orcid.org/0000-0002-2292-4816)
- Ping Yan (ORCID: https://orcid.org/0000-0003-4210-4580)
- Jiaying Cheng
- Xuejie Jiang (ORCID: https://orcid.org/0000-0002-0178-691X)
- Zhiquan Long
- Fang Liu (ORCID: https://orcid.org/0000-0002-1780-1723)
- Yujiao Zhang (ORCID: https://orcid.org/0000-0003-0699-6235)
- Ling Jiang (ORCID: https://orcid.org/0000-0002-2093-6741)
- Baoyi Yuan
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/cam4.70102
- Citations
- 3
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province