Vaccine‐induced humoral response of BNT162b2 and mRNA-1273 against BA.1, BA.5, and XBB.1.5. (sub)variants 6 months after a homologous booster: is immunogenicity equivalent?
Although the decrease in the humoral response was observed with both mRNA vaccines over time, a more sustained response was observed with the mRNA-1273 vaccine. Moreover, the emergence of Omicron-based variants causes a reduced neutralizing capacity, notably with the XBB.1.5. subvariant. The administration of subsequent boosters would therefore be needed to restore a sufficiently high neutralizing response.
Authors
- Jean‐Louis Bayart (ORCID: https://orcid.org/0009-0009-4802-7302)
- Julien Favresse (ORCID: https://orcid.org/0000-0002-9805-049X)
- Loris Wauthier (ORCID: https://orcid.org/0000-0002-8937-8186)
- Constant Gillot (ORCID: https://orcid.org/0000-0002-4151-9760)
- Roberto Cupaiolo (ORCID: https://orcid.org/0000-0001-7847-0086)
- Laurent Blairon (ORCID: https://orcid.org/0000-0003-0304-7624)
- Alain Wilmet
- Julien Cabo (ORCID: https://orcid.org/0000-0001-5630-7114)
- Marc Elsen
- Marie Tré‐Hardy (ORCID: https://orcid.org/0000-0003-4915-1339)
- Ingrid Beukinga (ORCID: https://orcid.org/0000-0002-0552-1775)
- Jonathan Douxfils (ORCID: https://orcid.org/0000-0002-7644-5298)
- Mélanie Closset (ORCID: https://orcid.org/0000-0002-0553-1981)
- Clara David
- Jean-Michel Dogné
Institutions
- Université Libre de Bruxelles (BE)
- University of Namur (BE)
- Clinique Saint Pierre (BE)
- Clinique Saint-Joseph (BE)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Hôpitaux Iris Sud (BE)
- UCLouvain (BE)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e36116
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39