Attenuation of brown adipocyte whitening in high‐fat diet‐induced obese rats: Effects of melatonin and β‐hydroxybutyrate on Cidea, Fsp27 and MT1 expression
The combined oral administration of BHB and melatonin successfully prevented the whitening of BAT in obese rats fed an HFD, indicating its potential as a therapeutic strategy for obesity-related BAT dysfunction. The synergistic effects of this treatment underscore the potential of a combined approach to address BAT dysfunction in obesity.
Authors
- Sayed Mohammad Shafiee (ORCID: https://orcid.org/0000-0002-9221-2267)
- Mohammadarian Akbari
- Omid Vakili (ORCID: https://orcid.org/0000-0002-9103-872X)
- Mohammad Hasan Maleki (ORCID: https://orcid.org/0000-0002-0095-4264)
- Motahareh Taghizadeh (ORCID: https://orcid.org/0000-0003-0256-4910)
- Sara Khakshournia
- Emad Heydarnia
- Mahroo Zeynolabedinzadeh
- Fateme Omidi
Institutions
- Islamic Azad University, Science and Research Branch (IR)
- Iran University of Medical Sciences (IR)
- Shiraz University of Medical Sciences (IR)
- Islamic Azad University Medical Branch of Tehran (IR)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2024-08-08
- DOI
- https://doi.org/10.1111/dom.15810
- Citations
- 7
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Shiraz University of Medical Sciences